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A Bayesian Adaptive Basis Algorithm for Single Particle Reconstruction 1.0
File ID: 85574

A Bayesian Adaptive Basis Algorithm for Single Particle Reconstruction 1.0
Download A Bayesian Adaptive Basis Algorithm for Single Particle Reconstruction 1.0http://www.mathworks.comReport Error Link
License: Shareware
File Size: 7.4 MB
Downloads: 25
Submit Rating:
A Bayesian Adaptive Basis Algorithm for Single Particle Reconstruction 1.0 Description
Description: 3D reconstruction algorithm for electron cryo-microscopy
Traditional single particle reconstruction methods use either the Fourier or the delta function basis to represent the particle density map. We propose a more flexible algorithm that adaptively chooses the basis based on the data. Because the basis adapts to the data, the reconstruction resolution and signal-to-noise ratio (SNR) is improved compared to a reconstruction with a fixed basis. Moreover, the algorithm automatically masks the particle, thereby separating it from the background. This eliminates the need for ad-hoc filtering or masking in the refinement loop. The algorithm is formulated in a Bayesian maximum-a-posteriori framework and uses an efficient optimization algorithm for the maximization. Evaluations using simulated and actual cryogenic electron microscopy data show resolution and SNR improvements as well as the effective masking of particle from background.

License: Shareware

Related: Filtering, adhoc, Masking, refinement, formulated, eliminates, Background, Automatically, masks

O/S:BSD, Linux, Solaris, Mac OS X

File Size: 7.4 MB

Downloads: 25

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